Background: Maternal satisfaction with delivery care service is used to measure the ability of services provided to meet their expectation. Currently, most of the mothers who got health care and delivery services from the public health hospitals and specifically at Woldia hospital have complain about the quality of health care deliveries and they are dissatisfied on delivery service provider. The objective of this study was to assess the level of maternal satisfaction on delivery service and associated factors at Woldia comprehensive specialized hospital. Method: Cross sectional study was conducted on 230 respondents from February 15 April 5. Structured questionnaires that adopted from national maternity service questioner were used. The collected data were checked for completeness and consistency before being coded, entered and analyzed using Statistical Package for the Social Sciences (SPSS) version 20 and AMOSS 22and to analyze Structural Equation Modeling (SEM) Smart PLS 3.0 statistical software were used. The structural equation modeling was applied to identify predictors of mothers’ satisfaction using Smart PLS 3.0. Result: In this study level of maternal satisfaction on delivery service was 63%. Hospital structure and obstetric history were directly affecting maternal satisfaction. The coefficient of determination R 2 =0.727 for the dependent variable maternal satisfaction which indicates that the exogenous variable hospital structure and obstetric history together explain about 72.7% of the variation in the dependent variable Maternal satisfaction. Conclusion: Hospital structure has strong effect on maternal satisfaction and obstetric history has a moderate effect on maternal satisfaction. Latent variable Hospital Structure has strong statistically significant correlations with its corresponding indicators or manifest variables.