Background: A stroke occurs when blood supply to the brain is blocked or ruptured, resulting in the death of some brain cells due to a lack of oxygen. The primary goal of this research was to identify factors that jointly affect the functional ability and time to death for adult stroke patients at Felege Hiwot Referral Hospital. Method: The study was carried out using a retrospective cohort study design from 298 randomly selected adult stroke patients in the medical ward outpatient clinic at Felege Hiwot Referral Hospital, Bahirdar, Ethiopia. The data was collected using the patient’s chart under the follow-up period from September 2018 to August 2020. To compare survival times, the Kaplan-Meier survival estimate and the Log-rank test were utilized. The Joint model of longitudinal and time to event model was used to identify factors that jointly affect functional ability and time to death. A generalized linear mixed-effects model and Cox proportional hazard model were used for longitudinal and survival outcomes of the data. The longitudinal and survival models of the two models were linked by their shared unobserved random effects. Result: From a total of 298 patients, about 107(36%) were death and 191(64%) were censored. The overall mean and median estimated survival time of stroke patients under study was 28 and 32 months respectively. Estimates of the association parameter in the joint analysis were highly significant ( =0.2888(p-value <0.0001) and = 3.2562(pvalue=<0.0001)) and model parameters were estimated with lower standard errors, providing evidence of joint model selection. Therefore age, diabetes disease, cholesterol level, and atrial fibrillation patients were significantly associated with the poor functional ability and time to death of adult stroke patients. Conclusion: Under this investigation, elder patients, high cholesterol levels, diabetes patients, and atrial fibrillation patients were with high poor functional ability rate and death rates, therefore, such patients need high intervention.