The major purpose of this paper is 10 examine the historical outline of epidemics in Rayya Qobbo Warada during the twentieth century. The focus of this the sis is the risk/actors and consequences of the outbreaks of epidemics in the study area and measures that have been taken by society, the government and non-governmental organizations to mitigate the devastation of epidemics. Human interactions with the environment and the changes that brought latter are pillars in the patterns of history of epidemics in the district for the last hundred years. This environmental change brought various human and animal diseases during the period under study. Malaria, small pox, typhus, cholera, meningitis, measles and HIV/AIDS were serious diseases that took or at least negatively affected the lives of many people in the district. Therefore, the result of this study shows that the majority of diseases of the population of Rayya Qobbo were communicable disease due to lack of sanitation, unhygienic environment, malnutrition, overcrowded housing situation, inadequacy and unavailability of public service. The problem was aggravated during drought and famine times, migration of non-immune population, interruption of the health service due to insurgent forces, war and conflict, change of government and lack rJj infrastructure. Throughout the paper attempts have been made to identify the major epidemics to give a general picture of the historical development at various diseases in time.