The purpose of this research was to assess the practice of CPD in Secondary Schools of Angot Woreda in North Wollo Zone. The research tried to find out the status of school based CPD, Challenges that affect the implementation of CPD and stakeholders’ support & follow up the activities on CPD implementation. Descriptive survey design was employed to to answer the basic research questions. The survey sample consisted of two General secondary schools, four school leaders, two CPD facilitators/coordinators & 104 teachers. These groups of samples were selected by using purposive sampling technique for two secondary schools, four school leaders, two CPD facilitators/coordinators and simple random sampling technique for 104 teachers. Data collection instruments like questionnaire, interview & document analysis were used. Both the qualitative and quantitative methods which are convenient for social science research were used in this study. To analyze the data collected through questionnaire, mean and standard deviation were employed. The findings of the study indicated that the status of teacher’s practices on professional development activities such as mentoring, portfolio development, conducting action researches, facilitating group discussions and peer observations, and evaluating the overall successes and failures of the implementation processes were inadequate. The major challenges identified were, lack of training manuals, irrelevance and un clarity of the available training manuals, lack of trained facilitators, insufficiency of supports provided for teachers growth, insufficient allocation of budget, and school systems were not in the way that can satisfy the training needs of teachers. To overcome the challenges encountered, recommendations have been forwarded. These include: orienting teachers in advance with the overall contents of the professional growth, motivating teachers to willingly take more responsibilities in the implementation process, employing trained facilitators and supervisors, and allocation of sufficient resources to effectively achieve the intended goals.