Schistosoma mansoni infection is one of the major public health problems in many developing countries including Ethiopia. The aim of this study was to determine the prevalence and associated risk factors of S. mansoni infection among school children of the two selected primary schools in Bahir Dar Zuria District cross-sectional study was conducted from December 2019 to February 2020. A structured questionnaire was used to collect data about the risk factors of S. mansoni infection in the study area. Stool specimens were collected and examined for S. mansoni using direct wet mount and formol-ether concentration technique. Data entry and analysis were done using SPSS version 21software. Descriptive frequencies like cross tabulation was calculated to describe the study variables. Binary and Multivariable logistic regression analysis were undertaken to determine the presence and degree of association between dependent and independent variables. The result of the study showed that from the total of 398 faecal samples examined 49 (12.3%) of the children were positive for S. mansoni infection. The major determinant risk factors for S. mansoni infection were Frequent swimming in water (AOR: 3.672; 95%CI: 594-22.705; P=0.029),water contact habit while crossing the water bodies (AOR: 5.19; 95%CI: 2.465-10.931; P=0.000),irregular shoe wearing habit (AOR: 6.205; 95%CI: 2.286- 16.843; P=0.000), poor knowledge (AOR: 3.369;95%CI:1.475-7.69;P=0.004) and parental illiteracy (AOR:3.168,95%CI:1.211-8.291; P=.004) were significantly associate with S. mansoni infection. Moderate prevalence of S. mansoni infection was discovered among the present study. Integrated control programs including, improve sanitation, provision of safe water supply and latrines to reduce human water contact and regular health education programs are recommended to prevent and control S. mansoni infection in the study area. Keywords: Schistosoma mansoni, Prevalence, School children, Bahir Dar Zuria District, Ethiop