Abstract:
A congenital malformation (CM) or birth defect is a structural or functional abnormality observed
in children. CMs occur during intrauterine development of embryo or fetus. It may be visible before
birth, at birth or later in life, and are major causes of children’s hospital admissions and deaths. The
aim of this study was to assess the prevalence and the associated risk factors of CMs in Bair Dar
and Gondar, Ethiopia. An institution-based, retrospective cross-sectional study was conducted in
four governmental hospitals where 61,934 infants were born from September 2015 to December
2019. Among these, 736 (1.2%) infants were born with CMs, and the types of CMs were identified.
To identify associated risk factors, maternal medical history books of all CM positive (736) and 681
CM negative newborns (736+681=1417) were consulted. The data were collected using a semistructured
checklist. The most frequent types of CMs were neural tube defects (39.7%), followed by
Oro-facial clefts (23.6%), cardiovascular system defects (10.3%) and Down syndrome (7.1%). Lack
of folic acid supplementation (AOR=9.79, 95% CI: 6.89-13.92), presence of chronic disease
(AOR=3.25, 95% CI: 2.29-4.60), intake of drugs (AOR=19.93, 95% CI: 13.5-29.3), consumption of
alcohol during pregnancy (AOR=1.64, 95% CI: 1.17-2.29) and maternal age (AOR=4.62, 95% CI:
3.24-6.58) were significantly associated with birth defects. These findings suggest that there is an
increasing burden of CMs in Bahir Dar and Gondar, Ethiopia. The findings reflect that sustainable
surveillance and registry systems are mandatory for intervention activities. In this respect, the
current study might fill an important information gap on CMs in the study area. Further detailed,
nationwide, multicenter, retrospective/prospective investigations should be conducted to influence
policy and healthcare decision-making so as to reduce congenital malformations.
Key words: Associated risk factors, Congenital malformations, Newborns, Prevalence