Globally, Over 600 million schoolchildren are living with intestinal parasites. The prevalence of intestinal parasites among school age children in Ethiopia and Amhara region is 52% and 51% respectively. The study aimed to determine the prevalence and associated risk factors of intestinal parasitic infections among primary school children in Dera district, northwest Ethiopia. A school-based cross-sectional parasitological study was conducted from December 2019 to February 2020. The sample size was determined using a single population proportion formula. Students were selected from five primary schools by simple random sampling techniques. Stool samples were examined by wet mount and formol-ether concentration techniques. Questionnaires survey was developed to collect different risk factors. Data were analyzed using SPSS version 25.0. Chi-square (χ2) test and Logistic regression was used to measure the association of risk factors and strengths or degree of association between the prevalence of intestinal parasitic infections (IPIs) and associated risk factors. Of the 382 students who were examined for IPIs, 238 (62.3%) of which (61.8%) males, and (62.8%) females) was positive for one or more intestinal parasites. The prevalence of single, double, and triple infections was 136 (35.6%), 98 (25.7%), and 4 (1.05%) respectively. The prevalence of IPIs among the five primary schools were, 78 (74.3%) (Korata), 67 (61.5%) (Mirafe Mariam), 34 (58.6%) (Wagira), 35 (58.3%) (Gibtsawit), and 24 (48%) (Enbosa Maseria). Nine species of IPIs were detected. Entamoeba histolytica/dispar was the predominant species, 113 (29.6%) followed by Hookworm, 83 (21.7%), Schistosoma mansoni, 43 (11.3%), Taenia saginata, 35 (9.2%), Giardia lamblia, 20 (5.2%), Ascaris lumbricoides, Hymenolepis nana, and Enterobius vermicularis 16 (4.2%) each, and Trichuris trichura, 2 (0.5%) in descending order. Statistically significant differences in prevalence of IPIs (P < 0.05) were observed due to variations in schools, family size, and knowledge for IPIs, using school toilet, open field defecation in the school compound, school water access, school water treatment, and a habit of school waste disposal. The family size greater than five (AOR = 1.8; 95% CI: 1.004, 3.13), open field school waste disposal (AOR = 15.88; 95% CI: 1.91, 132.1), and poor knowledge about IPIs (AOR = 1.8; 95% CI: 1.1, 3.2) were the independent risk factors associated with the overall prevalence of intestinal parasitic infections. The prevalence of intestinal parasitic infection was high in Dera district. Health education, extending school-based deworming, and mass treatments are recommended. Keywords: Amhara, Ethiopia, Primary school, IPIs and School age children