Potato is one of the most important and widely grown vegetable crops in Estie woreda, South Gondar, Ethiopia. This crop contributes to a food source and as a cash crop. But farmers cultivate both (red and white tuber) potato genotypes with limited information about their productivity differences. Hence, the objective of the study was to compare the growth, productivity, disease resistance and palatability of red and white tuber potato genotypes. The methodologies used were household survey (community-based cross-sectional design) and field experiment. In the household survey, 384 samples were taken from the population of Lewaye and Gedayat kebeles using a simple random sampling technique. In the field experimental study, three plots with 1.5 m x 1.5 m size with 75 cm distance in each plot. Five red and five white tuber potato genotypes were planted and replicated three times using Randomized Complete Block Design (RCBD). There were two rows in each plot. The seed tubers were planted on the same date (December 4, 2019) using the recommended spacing of 75 cm x 30 cm between rows (interspacing) and plants (intraspacing) respectively and they were treated in the same ways. The data were collected from planting date to March 24, 2020 (harvesting time). The study showed that the white tuber potato genotype is cultivated more (57.6%) than red tuber potato genotype due to its superior in yield. On the other hand, the red tuber potato genotype is superior to early emerging, early growing, early flowering, early maturing, more disease resistance and palatability than white tuber potato genotype. Although the red tuber potato genotype had these qualities, the farmers prefer to cultivate white tuber potato genotype for its superior in yield. Because this is a onetime study, repeating the study would enable us to reach a conclusive decision. Key words/phrases: Disease resistance, taste, growth rate, potato, yield .