Hypertension has become a growing public health concern in developing countries. Hypertension is one of the most common complex genetic disorders, with genetic heritability averaging 30%. Many factors contribute to the development of hypertension which can broadly be categorized into two; modifiable and non-modifiable. The present study was performed to assess the association between ABO blood types and other factors with hypertension in Dangila and Durbete hospitals. A Hospital-based case control study was conducted from June to July 2020. Data was collected from a total of three hundred eighty four individuals who visited the hospital for medical attention. By using simple random sampling techniques, 192 case and 192 control subjects were selected. Necessary information on associated factors of hypertension was collected using a questionnaire.ABO and Rh blood group types were determined by taking a venous blood sample from the participants. Based on multivariate logistic regression, Age, marital status, residence, educational level, alcohol drink, animal source food consumption and physical activity were significantly associated with hypertension (p <0.05) but there was no statistically significant association between ABO blood group (X2=1.98, 3, N=384 and p=0.577) and Rh factor (X2 =0.62, 1, n=384 and p=0.557) with hypertension. Blood group O was the most prevalent blood group and AB was the least prevalent both in case and control study group. Under behavioral factors, alcoholic people were2.26 times hypertensive than non-alcoholic ones (p=<0.001, AOR 95% CL=2.26(1.38, 3.71)). Physically inactive people were 2.19 times more likely to develop the disease than physically active ones (p=0.006, AOR 95% CL= 2.19 (1.27, 3.54)).Regarding animal source food consumption, those who eat animal source food were1.48 times more susceptible than who do not eat animal source food (p= 0.014, AOR 95% CL=1.48(0.90, 2.41)). Hence, healthy lifestyle changes like change alcoholic use, promotion of balanced diet complemented by regular physical activity should be promoted to reduce the risk of hypertension. Key Words: Association, Behavioral Factor, Blood groups, Hypertension, Socio-demog