Testing and Evaluation of Possible Control Techniques Against Varroa Mite (Varroa destructor) at Local Conditions of ICIPE-YESH Project Intervention Districts, Western Amhara Region, Ethiopia The study was conducted in Bahir Dar Zuria, Burie and Hulet Eju Enesie districts of Amhara region from October 2018 to April 2019 to identify the seasonal dynamics and infestation rate of Varroa mite ; to identify and evaluate how the possible Varroa mite control techniques could control and minimize the infestation levels in local honey bees; ;and to evaluate the possible effects caused by each of the treatments on colony performances. For each experimental site 16 honeybee colonies were assigned randomly to four treatments. The treatment groups were Apicure dispenser, drone brood removal, powdered sugar and control. Initially data of pretreatment varroa mite infestation, total varroa mite pre colony, adult bee population and total sealed brood per colony were collected. Phoretic stage varroa mite infestation was determined by using powdered sugar roll method. The success rate of tested apicure dispenser techniques showed remarkable variation among other tested and evaluated techniques. The highest records of phoretic phase varroa mite infestation at Andassa experimental site was from drone brood removal treatment (17.18±1.41) while the lowest was from Apicure treatment (6.3±0.78). The lowest varroa mite infestation record was observed at Hulet Eju Enesie experimental site treated with apicure dispenser (3.11±0.61). The overall adult bee population across treatments of the experimental sites of Andassa, Burie and Hulet Eju Enesie were 16,357±224.6, 16,224.76±274 and 15,739.2±246.95, respectively. There was no significant difference (p>0.05) in adult bee population among experimental sites. However, there was a significant difference (p<0.05) in adult bee population among treatment groups. Adult bee population at Andassa was higher at control group (17,076±392) but lower in drone brood removal treated colonies (15,255±479). In the reproductive phase varroa mite infestation there was no significant difference (p<0.05) among treatment groups with in experimental site. On the other hand, there was significant difference (p<0.05) on sealed brood unit area among treatment groups in all experimental sites. However, there was no significant difference among experimental