The main objective of this study was to investigate the effect of plyometrics training on motor related physical fitness and handball skill in male handball project players among woreta town Amhara region Ethiopia. To achieve the purpose, experimental design was used. 30 male handball players of woreta town were taken comprehensive as a sample study their age were 12-14 years. Experimental group (n=15) performed both lower and upper extremity plyometrics training three days per week for three-month on squat jump, tuck jump, long jump, speed running, power throw and slalom agility dribbling and control group (n=15) however, did not perform this lower and upper extremity plyometrics training, both groups undergone normal handball training program. And both groups had taken pre and post-tests. So all subjects participated motor related physical fitness and skill performance test. 30m speed running, slalom 30m dribbling, throw and long jumping. The data was analyzed and compared with the help of statistical procedures in which arithmetic mean, standard deviation and paired t-test was used. The level of P<0.05 considered as significant level. The result showed that on 30m speed running test control group MD=-0.26 & P=.086 while experimental MD=0.4467&P=.003, long jump test control group MD=0.062 & P=.362 where as experimental MD=-0.0853 & P=.002, ball throwing test control group MD=0.4393 & P=.743 where as experimental group MD=-1.0634 & P=.004 and slalom 30m dribbling test control group MD=-0.5147& P=.063 while experimental MD=0.9513 & P=.008. There for lower extremity plyometrics training for twelve weeks are more effective in increasing speed and dribbling and upper extremity plyometrics is increased power ball throwing skill of male handball players of Fogera woreda woreta town. Generally the present study concluded that both lower and upper extremity plyometrics training had a significant effect of players handball skill performance through the selected handball skill tests. Hence, both lower and upper extremity plyometrics exercise is effective and beneficial for the enhancement of male project handball skill performance.