Maize is a major staple food crop for small holder farmers in Northwestern Ethiopia, in particular to North Mecha district. However, agronomic management practices such as approperate plant spacing and use of improved varieties are quite important for enhancing maize production. Hence, a field experiment was conducted during 2019 main cropping season at North Mecha district Northwestern Ethiopia to determine the ef ects of inter and intra row spacing on yield and yield components of maize varieties. The experiment consisted of the factorial combinations of two hybrid maize varieties (“BH-540” and “BH- 661”), three inter-row spacing (65, 75 and 85 cm) and three intra-row spacing (25, 30 and 35 cm) with a total of 18 treatments in RCBD with three replications. The results of the study had shown that there were highly significant dif erences due to the main ef ects of varieties on days to 50% tasseling, 50% silking, and 90% maturity. There was also highly significant dif erence due to the main ef ects of both variety, inter- and intra-row spacing on leaf area index, ear length and number of grains per row and ear diameter. A very highly significant interaction ef ect of variety, inter- and intra-row spacing on leaf area index, above ground dry biomass yield, grain yield and harvest index and highly significant in thousand grain weight. Generally, higher grain yield and above ground dry biomass were obtained from BH-661 at 65x25 cm (11.39 t∙ha −1 and 34.1 t∙ha −1) respectively. The highest grain yield (11.39 t∙ha −1) and (10.82 t∙ha −1) was obtained at interaction of 65x25 cm spacing in BH-661 and BH-540, respectively while the lowest grain yield (5.71 t∙ha −1) was obtained from 85×35 cm spacing in BH-540. The result of economic analysis showed that the maximum net benefit (ETB 90408.75 ha -1) was obtained at spacing of 65x25 cm in BH-661. Therefore, based on economic analysis it can be conclude that optimum inter and intra row spacing (65x25 cm) combinations is promising for BH-661 hybrid maize variety production in main season of North Mecha district and similar agro ecologies. For better confirmation of the result, this one year experiment needs to be repeated at multi-locations and in dif erent seasons. Keywords: BH-540, BH-661, Inter-row spacing, Intra-row spacing, Plant Density, Yield