Bread wheat (Ttriticum aestivum L.) is the most important crop in Farta district and in Ethiopia as well. However, its productivity is very low as compared to the world, which is due to poor agronomic practices like inappropriate seeding rate, improper adjustment of row spacing, and other factors. Therefore, a field experiment was conducted at Debre Tabor Agricultural Research Sub-center experiment station during 2019 main cropping season to evaluate the effect of seeding rate and row spacing on yield and yield component of bread wheat. Four levels of seeding rates (125, 150, 175, and 200 kg ha-1) and four levels of row spacing (20, 25, 30, and 35 cm) were tested in factorial arrangement in randomized complete block design with three replications. The results from analysis of variance showed that some of the yield and yield related components like spike length, seed per spike, hectoliter weight, and thousand grain weight were none significantly (P > 0.05) affected by the main effect of seeding rate, and row spacing. In addition to these, non-effective tiller were non- significantly (P > 0.05) affected by the main effect of seeding rate, but very highly significantly (P > 0.001) affected by main effect of row spacing. Plant height were highly significantly (P < 0.01) affected by the main effect of seeding rate, but none significantly (P > 0.05) affected by the main effect of row spacing. The interaction of the two factors (seed rate and row spacing) affected effective tiller, total tiller, grain yield, biomass yield, straw yield, and harvest index. Hence, seeding rate of 175 kg ha-1 with 30 cm row spacing gave higher grain yield (3.61 ton ha-1), and it is economically profitable with MRR of 107.84 % and net benefit of Birr 99525.7 ha-1. Based on this, 175 kg ha-1 seeding rate with 30 cm row spacing is recommended for wheat production in the study area. However, further study has to be done under different seasons and locations to arrive at a dependable recommendation. Keywords: Bread wheat, grain yield, row spacing, seeding rate