The purpose of the study was to investigate educational challenges and opportunities blind students faced in Mengesha Jenberie Primary School. Qualitative research approach particularly case study research design was utilized to carry out the research. Semi structured interview guides were held with 4 Blind Students and 2 principals which were selected using comprehensive sampling technique. In addition, FGD was employed with 8 Blind Students, 10 teachers and 6 parents which were selected using comprehensive, criterion and availability sampling techniques respectively. Besides, observation and document analysis were also employed. The data were discussed qualitatively in line with the basic research questions and theoretical frameworks. Results of the analysis indicate that Blind Students gain access to learn with sighted peers; exposure to policy documents; support from SNE teachers, principals and sighted peers. Besides, the normal class size and sitting arrangement were some of opportunities. This implies that there are motivating factor for Blind students who were suffering from educational challenges. However, the challenges they faced with poor instructional process used by teachers; absence of lack of Braille written materials and inadequate materials and equipment and ill-equipped service center and its delivery. In addition, Blind Students were challenged with: Issue of exams; nonexistence of IEP; and poor support from some of the school communities. This implies that even though there are some opportunities to support Blind Students in the School but still now there is a serious problem that restricts to use their full potential in their learning. Finally, some of the recommendations, such as the school: ought to provide training to teachers; need to minimize obstacles in exams; need to render library and resource room services; and create collaboration among stakeholders At last future research is recommended with large sample size to be generalized to a wider population.