The study sought to determine the Balanced Scorecard measures on supply chain performance at Ethiopian Pharmaceutical Supply Agency Bahir Dar Hub. The objective of the study was to measure the performance of supply chain of Ethiopian pharmaceutical supply agency Bahir Dar Hub from BSC approach. The research designs involved were descriptive and inferential explanatory design. Data were collected from 97 Ethiopian pharmaceutical supply agency Bahir Dar Hub employees using a survey questionnaire thatwas administered to employees and conducted by researcher. Tables were used to present data. Descriptive statistics like mean and standard deviation were used to analyze demographic and each constructs under investigation, whereas inferential statistics like Correlation and regression analysis were used to measure the relationship between independent (Balanced Score Cardmeasures) and dependent (supply chain performance). The result of the study established that the Balanced Score Card measures are greatly used to establish the supply chain performance at Ethiopian Pharmaceutical Supply Agency Bahir Dar Hub. Learning and growth measures(b=0.382) has the most positive influential effect on supply chain performance, followed by Customer measures, financial measures and internal business process measures (b = 0.265, b = 0.180, and b = 0.156) respectively at p value <0.001. It was also found that there is a significant relationship between BSC measures and supply chain performance represented by R 2 value of 0.860 which translates to 86.0% variance explained by the four independent variables of financial measures, customer satisfaction, internal business processes, learning and growth measures. The overall supply chain performance of Ethiopian Pharmaceutical Supply Agency Bahir Dar Hub is moderate performance. But, in contrast to this there are problems related to clear financial goals, uses promotion to gain customer, Experience sharing with suppliers and adding value to the employees from Balanced Score Card dimensions. Therefore from the result it can be concluded that Balanced Score Card measures at Ethiopian Pharmaceutical Supply Agency Bahir Dar Hub is strongly affecting their supply chain performance. It was also recommended that the company should keep using Balanced score Card as performance measurements as holistic performance perspective in such a way that they can solve problems raised by Employees. Finally, based on the limitation of this study, further research can be done on a wider group of companies to establish whether the Balanced Score Card measures are better in measuring Supply chain performance in pharmaceutical industry.