Energy crisis has emerged as a serious issue all over the world due to rapid increase of the population, socio economic development, living standards with the fast growing of industry. Ethiopia facing similar crises that has resulted infrequent power failures and load shedding throughout the country for past years. Identification and utilization of new renewable energy sources site is of crucial importance to reduce the energy shortage and fossil fuel dependency throughout the country. This study aims to investigate the assessment of the site from micro to small scale hydropower potential in the Chemoga River, Upper Blue Nile Basin, Ethiopia. Stream flow data from 1974-2010 and height information measured using total station were collected. Analytical hierarchy process was chosen in combination with GIS as a method of multi criteria decision making to prioritize and select best hydropower site. Arc GIS, MCDA, GPS and Google earth were used for visualization, data analysis and interpretation. From all potential sites were site 1 and site 6 have maximum (3.81 MW) and minimum (0.71MW) power potential respectively. The maximum installed capacity for 30% time of exceedance and the minimum firm power for 90% FDC time of exceedance were 10.69 MW and 0.4 MW respectively. The total annual energy potential of the selected sites was estimated about 86.18 GWh, 13.65 GWh and 2.92 GWh for 30 %, 50 % and 90 % of time exeedance respectively. From the six potential sites in the study area, five sites are small scales and the one site is a mini hydropower scale. This requires further study. Therefore, responsible institution should install gauge station to measure stream flow which is pertinent information‟s for hydropower study.