Internet of Things and Cloud Computing aim at enabling a variety of next generation technologies, such as Intelligent Wireless Sensor Element Networks (WSNs), smart cities, smart homes, and smart health care system. Due to the tremendous rise of cloud computing and the IoT paradigms, the chance of remote monitoring of patients in real time by a distant medical skilled professional has become possible and patients will get health care services at home. To achieve this, the patient’s medical data needs to be stored in the Cloud. However, patient medical information stored in the cloud is highly sensitive since, the cloud storage and its network become open to many attacks. For this reason, there should be a system that patients’ medical information does not get exposed to malicious users. This makes strong security system is a requirement for the productive global deployment of central smart healthcare systems. Additionally, the health devices used in the IoT enabled healthcare system are resource constrained. To implement protection mechanisms for such applications cryptography and steganography are shown to be the best choice. These are the two standard ways offered to produce greater security. Crypto-steganography combination overcomes each other’s weakness and makes difficult for intruders to attack or steal sensitive information. This thesis presents a proposed security system to increase the security of medical data access using Diffie and Hellman algorithm secret key sharing whereas, encryption and decryption is carried out using Deoxyribo Nucleic Acid (DNA) cryptography and Least Significant Bit (LSB) steganography hiding principle using MATLAB 2018a tools. The proposed system is evaluated using Encryption time, throughput, Peak Noise to Signal Ratio (PSNR) and Mean Square Error (MSE). The implemented proposed system shows it is more secure and efficient than the Advanced Encryption standard and LSB algorithms based on performance evaluation that has been done for the developed proposed system.