Stunting is one of the most common causes of morbidity and mortality among children especially in developing countries and it is the underlying cause of one third of the child deaths each year before their fifth birthday. Similarly, It is still one of the major public health problems in Ethiopia, particularly affecting a significant number of children as the most vulnerable group. Access to clean water and sanitation has been identified as one of the major underlying determinants of child nutrition status. However, the risk factors of under nutrition are diverse and could potentially change in space as well as in time. To assess the association between household sanitation practices with stunting status of pre-school children aged 24-59 monthsat fartadistrict,Northwest, Ethiopia, 2018. Based cross-sectional study design was conducted at Farta district among pre-school children aged 24-59 months from March 9 to May 08 /2019 G.C, 2019. Farta district has a total of 201,500 catchment population and 614 study participants were selected using Simple random sampling technique was used for selection of study kebeles and systematic random sampling technique for study subjects with their mothers from selected kebeles. Data collection was including interviewer administered structured questionnaire. The data were coded and entered to Epi-Data version 3.1 and exported to SPSS version 20 for analysis. Binary logistic regression was used for analysis. A total of 610 preschool children with response rate of 99.4% were participated in the study. The overall stunting status among preschool children was found to be 255 of study participants [41.8% (95% CI: 37.4, 45.6)] were reported that stunted. wealth status, being richest or poorer [AOR=1.457(95% CI: 1.127, 4.131)], sanitation status, being having good sanitation practice orpoor sanitation practice [AOR=1.211(95% CI: 0.129, 1.343)], were factors associated with stunting. Stunting status among preschool children was found to be high. sanitation practice and wealth status were factors associated with stunting. Therefore, appropriate nutrition education should be given.