Abstract Introduction: Schistosomiasis is one of the most prevalent neglected tropical diseases and considered. The magnitude and impact of schistosomiasis is high in Ethiopia although several control methods have been conducted. When Schistosoma is co-infected with Salmonella, it aggravates complication of the disease. Objective: The aim of this study was to assess the magnitude and associated risk factors of Schistosoma mansoni and its co infection with Salmonella species among primary school children in rural Bahir Dar, Northwest Ethiopia Methods: School based cross sectional study was conducted at Sebatamit primary school from April 2018 - March 2018. A total of 422 study participants were selected by systematic random sampling. Stool samples were collected and transported to Bahir Dar University Microbiology and Parasitology laboratory and conducted by Kato-Katz technique. Stool samples positive for S chistosoma mansoni were transported by Carry Blair transport media to Amhara public Health Institute for isolation of Salmonella species. Then, the stool samples were cultured on Xylose Lysine Decarboxylase agar and suspected colonies were further tested by different biochemical tests. The data were analyzed by statistical package for social science version 23. Any statistical values with p<0.05 were considered as statistically significant. Results: - The overall prevalence of Schistosoma mansoni infection was 105/422 (24.9%). Among these, 66 (62.8%) were males and 39 (37.2%) were females. However, this variation among sex was not statistically significant (p=0.659). 66 (62.8%) of the infected children were found in age group of 11-14 years and they were 2.28 more likely to be infected than 15-18 years. 76 (71.4%) of the study participants had light infections. The overall mean intensity of Schistosoma mansoni in the study was 106.16 EPG. Age (p=0.013) , Swimming habit (p=0.00 ), participating in irrigational activities (P=0.03) and washing clothes in the river (P=0.039) were associated with Schistosoma mansoni infection. There was no Schistosoma mansoni and Salmonella species co infections observed in this study. Conclusions: In this study, the overall prevalence of S.mansoni was 24.9%. The majority of infection intensity was light infections. There was no S.mansoni and Salmonella spp observed. Keywords: Schistosoma mansoni, Salmonella species, Sebatamit, Northwest Ethiopia