Malaria remains significant development and health problem in 11K' world especially in Africa countries .. .\ cross-scctioual siudv M~~ designed and conducted in /1 ncded district easi Goiam Zone Amhara Region from October 2015 to December 201.'i to assess knowledge, attitude. practice and associated risk factors of maiana. t\ total of >•l2 blood smear sli,k~ were· collected and stained with 10% Gcimsa stain for Plasmodium species identification, Using structured quesuounaires and interview, data were collected lrom households about knowledge. auirudc, and practice in relation to occurrence of malaria ~l'bc collected data "ere analyzed using SPSS (version 16) software. l he findings of the study indicated that the prevalence of malaria W<'IS 14 % (55!392\. lhc most prevalent malaria parasne was t'ivivax (34!.N2) 8.7%, 1(>1101\·"<l 1'. [olciparum 1141392) 3.(i'Yc, accounted and mixed infecriou iPlusntodlum vivax and Plusmodium [alciparum) "/39:?) 1.8%. t>r;.><·nce of mosquito breeding area near the houses of study participants was found to he the predictor of' Plasmodium infection l:\01<: 1.9. 95% Cl: ( 1.0- 3.7}1 (P<0.05 ). Study participants who wrongly assocuued malaria with other agents other than mosquitoes were thirteen limes more likely 10 be infi.'ct=rl by malaria than those correctly .associatcd the disease with mosquitoes [.'\OR: 13.9, 95% CT:(2.48- 78.63)] SniLiy paniciparus who lived in poorly constructed houses that allowed mosquitoes lo the inside of the house were sh: Times 11\0re likely attccred by malaria Lha11 those who lived in well contructeo houses [1\0H:6.04 95'Vo CJ ('.!.19-l6.65)J. In conclusion, the prevalence of malaria in the study area W1'S high .• Misconceptions about cause of malaria were observed among the residents. Health education sboukl he given lo crearc.aware11cs' about the cause of malaria in Anedcd 1 )i::.trit<. Key words: Aneded, Ethiopia, Malaria, I< 1\Ps. l'rcvalencc.