Morphogenetic traits are physical characters of an individual and the patterns of inheritance of these traits are autosomal dominant as well as autosomal recessive. The present study was conducted to assess the morphogenetic traits (earlobe, facial dimples, hair line shape, shape of thumb, rolling ability of tongue, presence or absence of mid digital hair, presence or absence of freckles, and hand clasping), blood group distribution and association between some morphogenetic traits and blood groups in Yismala preparatory and secondary school. In this research, from the total of 3010 students, 103 females and 197 males were randomly selected from Yismala preparatory and secondary school. Quantitative and qualitative method were used to collect data. SPSS version 20 was used to calculate chi-square test and other descriptive statistics. This research showed that right thumb clasper (62.67 5), right handed (95.66%), straight hair shape (99.66), non dimpled (60 %), non freckle (100 %), non tongue roller (54.66%), non mid digital hair (56.66%), hitchhiker‟s thumb (58.66%) and freehung ear lobe position (94.33%) were the most frequently observed morphogenetic traits. Wow ever, left thumb claspers (37.33%), left hand type (3.66%), ambidextrous (0.33%),Window’ speak (0.33 %) dimpled cheek(40%), freckle (0%), tong roller (45.33%), mid digital hair (43.66%), straight thumb (41.66%) and attached earlobe (6%) were the least frequently observed morphogenetic traits. The association of morphogenetic traits with genders was assessed. The p value of blood (0.083), dimples (0.063), tongue rolling (0.07), and ear position (0.4) which were greater than 0.05 that indicates no association between gender for these traits and the p value of mid digital hair (0.00), hand clasping (0.00) and finger shape (0.023) were less than 0.05 which indicates the association of traits and sex. There was no statistics computed for freckle traits because there were no any freckle traits in both gender. The association of these morphogenetic traits and blood groups were also assessed. So the p value of dimple (0.00), Earlobe position (0.023), the shape of thumb (0.01), hand clasping (0.01) and tongue rolling (0.02) were less than 0.05 which indicates association between these morphogenetic traits and blood groups. The p value of handedness (0,15), hair shape (0.6) and mid digital hair (0.41) was greater than 0.05 which indicates no association between blood and these traits. Statistical descriptive analysis show that Blood group frequency,AB (6.3%) < B (21 %) < A (35%) < O (37.7%) was observed with the highest frequency of blood group were Rh+( 89.7%) and lowest frequency of studied population were Rh- (10.3%) . Key words: Morphogenetic traits, ABO blood groups, Rh blood groups, Yismala.