Abstract The effect of Space weather is usually linked to disturbances in the ionosphere, which is gradient of TEC. This has significant effect especially for GPS users causing degradation in range measurements and loss of lock by the receiver of the GPS signal. So, this study describes the ionospheric TEC variation in East Africa equatorial anomaly region by taking the 2016 data from Bahir-Dar (bdmt) (11.6 o N, 37.36 o E), Debark (debk) (13.15 0 N, 37.89 0 E and Misamfu research institution (kasm) (-10.17 0 S, 31.23 0 E) GPS stations. The data has calibrated by using a RENIX-TEC software and the calibrated data has been imported in to a MATLAB code and the results of the value of VTEC for each quiet and disturbed days, months and seasons are obtained. TEC value is maximum at about 10:00-14:00 UT in each day at the time where the sun is overhead. Similarly, the maximum TEC is recorded in April (equinox) and is minimum in July (solstice). When we compare the seasonal variation of TEC, it is maximum in spring and Autumn seasons that is on March equinox and September equinox while minimum in winter and summer solstices. And also, ionospheric TEC variation is maximum in Bahir-Dar and is minimum in kasm. Keywords: Total Electron Content (TEC), Equatorial Ionization Anomaly (EIA), GPS Global positioning system