VOLTAMMETRIC DETERMINATION OF PARACETAMOL IN PHARMACEUTICAL TABLET SAMPLES USING ANTHRAQUINONE MODIFIED CARBON PASTE ELECTRODE

Welday, Teklay

dc.contributor.author	Welday, Teklay
dc.date.accessioned	2018-11-09T04:21:34Z
dc.date.available	2018-11-09T04:21:34Z
dc.date.issued	2018-11-09
dc.identifier.uri	http://hdl.handle.net/123456789/9141
dc.description.abstract	Voltammetric method was developed for the direct quantitative determination of paracetamol in pharmaceutical tablet samples based on anthraquinone modified carbon paste electrode. The electrochemical oxidation and determination of paracetamol content were easily carried out using a variety of voltammetric techniques. The electrochemical measurements were carried out on anthraquinone modified carbon paste electrode in various buffer solutions in the pH range from 3 to 10 by cyclic voltammetry and square wave voltammetric techniques. The dependence of anodic peak current and peak potential on the pH of 0.1 M phosphate buffer solution was investigated. The oxidative peak current response of the modified carbon paste electrode showed linear dependence on the concentration of paracetamol in the range 5 to 150 ppm. Excellent recoveries (93.5%), low limit of detection (0.13 µM), and limit of quantification (0.43 µM) validated the developed method for its applicability for determination of paracetamol in real samples. Finally, the proposed method was applied for paracetamol determination in four brands of pharmaceutical tablet samples such as Julphare aldol, Panadol adva., Kelvin and Para denk. Keywords: paracetamol, tablet formation samples, anthraquinone modified carbon paste electrode, cyclic voltammetry, square wave voltammetry.	en_US
dc.language.iso	en	en_US
dc.subject	CHEMISTRY	en_US
dc.title	VOLTAMMETRIC DETERMINATION OF PARACETAMOL IN PHARMACEUTICAL TABLET SAMPLES USING ANTHRAQUINONE MODIFIED CARBON PASTE ELECTRODE	en_US
dc.type	Thesis	en_US