Parthenium hysterophorus commonly known as congers grass is a noxious weed. The weed is dominant in many parts of Ethiopia and became beyond the control of the smallholder farmers and the government. There have been Parthenium eradication campaigns through uprooting and burning, but it is still spreading. Recently farmers are using Parthenium for compost making. Compost production and utilization has been shown to be a great asset towards cleaner environment as it contains remarkable macro-nutrients. Therefore, this study was carried out at Woldia Woreda, north Wollo zone, to determine some selected macronutrient content of compost made from Parthenium and its effect on seed germination of vegetables. Selected macronutrients were determined based on standard procedures and pot experiment was undertaken for vegetables seed germination. The results revealed that low nitrogen (0.31%), moderate phosphorus (0.14%), high potassium (109.72ppm) and high calcium (314.1ppm) but low in C/N ratio (6:39) were recorded in Parthenium made compost. The results also revealed that compost prepared from Parthenium has positive effect on vegetable seed germination and growth. About (100%) of cucumber seeds and onion seeds sown in Parthenium weed compost were emerged in the first 15 days after sowing. The toxic weed Parthenium used in this experiment is thus converted into valuable compost resources with remarkably moderate concentrations of nutrients and can be used as amendment of soil for growth of crops. Key words: Compost, macronutrients, Parthenium, seed germination