Hot pepper bacterial wilt caused by Ralstonia solanacearum is a destructive disease of Capsicum annuum in Ethiopia. One of the main constraints that contribute to the low productivity of pepper in the country is failure due to wilt disease. This disease is caused by R. solanacearum. Currently, the common management strategies include mechanical removal of infected plant materials and the application of bactericidal chemicals. However,the continuous and indiscriminate use of chemicals to manage the disease results in accumulation of harmful chemical residues in the soil, water and grains. Therefore, this study was aimed at evaluating the antibacterial activity of some selected medicinal plants against R. solanacearum.The antibacterial activities of methanol leaf extracts of Eucalyptus citriodora, Lantana camara, Ricinus communis, Justicia schimperiana, Melia azedarach and Burcea antidysenterica were evaluated in vitro using disc diffusion method. Fresh leaves were collected, dried at room temperature under shade and ground to fine powder. Extraction was carried out using maceration method and the phytochemical composition of extracts was qualitatively analyzed. R.solanacearum was isolated using CPG medium from infected C. annuum plants collected from Mankusa. The isolate was characterized in terms of catalase, gram staining, potassium hydroxide, and starch hydrolysis tests. The biochemical tests of R. soalacearum showed positive results for catalase, gram staining, starch hydrolysis test and potassium hydroxide test were positive. Higher percent yieldextract, antibacterial activity and relative percentage inhibition were obtained from E. citriodora followed by R.communis. Extracts of all species showed antibacterial activity except M. azedarch. Significant differences in inhibition zone diameter were recorded between species and among serial test concentrations. The widest inhibition zone was recorded by E.citriodoraandR. communis. Unlike others, extracts of E. citriodoraand R.communis had alkaloids, flavonoids, phenols, Terpinoid, Saponin and tannins. The remaining species lacked one or more of these secondary metabolites. The extracts of E.citriodora were found to have higher phenolic compounds, and this was positively correlated with inhibition zone diameter at all test concentrations suggesting its potential antibacterial activity. Keywords:Capsicum annuum, crude extract, Inhibition zone,R. solanacearum