Anthrax is caused by a gram-positive, non motile and spore-forming bacterium called Bacillus anthracis. Ruminants such as cattle, sheep and goats are commonly affected ani¬mals in which they usually contract the disease through in¬gestion of soil-borne anthrax spores and die acutely. This study assesses the clinical cases of anthrax disease and possible risk factors among ruminant animals in Tach Gayint woreda, Northwest Ethiopia. Based on the agro-ecology, and accessibility of transport, five kebeles were selected and from these kebeles 120 study households were selected randomly. Then a questionnaire was administered to all of the sampled households. In addition, clinical survey of the last five years was done on the veterinary center of each kebele. From the clinical survey of 2012-2016, a mean number of anthrax cases of 6.74, 4.61, 9.74, and 3.22 in bovine (P < 0.05); 5.30, 4.13, 8.00, and 2.35 in ovine (P < 0.05); and 3.70, 2.83, 5.48, 2.22, and 3.55 in caprine (P > 0.05) were recorded during autumn, winter, spring, and summer respectively. The disease was higher during spring and autumn and low during summer season. In terms of species, based on the clinical case of 2012 - 2016, there was a significant mean difference among three ruminants with an overall mean of 6.08, 4.95, and 3.55 in bovine, ovine, and caprine respectively (P < 0.05) in which bovines were commonly affected followed by ovine and the least was caprine. Regarding agro-ecology, there was significance mean difference in the three ruminants among the different kebeles (P< 0.05). Significance mean difference was observed between Endiwa and the other four kebeles (P< 0.05), and between Aqeto and Dajat with higher cases at Endiwa and Aqeto respectively. Only in ovine and caprine significance variation was observed between Aqeto and Arb Gebeya in which ovine and caprine at Aqeto are more affected than Dajat’s. From 2012-2016, the disease shows a decreament due to the improvement of the extension service, awareness of the society, management of the animals in the woreda etc. Almost all 97 (77.5%) attend modern treatment method when their animals infected with anthrax, still there are some farmers 19 (15.8%) and 8 (6.7%) who treat their animals through traditional method. Around half of the farmers 53 (44.2%) still did not know about proper disposing of carcasses despite of around 67 (55.8%) of the farmers properly dispose died organisms. The veterinarian should create know how about the disease in the society and should vaccinate animals before the anthrax season and Kola should be give focus to supply the required services regarding the animals health. Key Words: Anthrax, Clinical case, ruminant Animals, Bovine, Ovine, and Caprine