The cholesterol levei» in the b/u;1</ and con.\-u1npli<»1 1if diet» rir.,:h 111 1.. holestero! or« closely related to each other. There IK1s been increasing r:vKience ilitlic<1tln$f that higlr plasma c}uJ/i!.\ler(1/ is :..1 risk fucior m...the d!!vt!lt11n11en1 of aiberoscterosis t111d coronary heart disease (CHl)j, The present i111'es11g(1!ion 'fa:s carried 011: for tile estimauon of cholesterol and .\011u:­ qualif); parameter. .... i'i1 buucr margarine and i·c?gt!.tahle ghee samptes tluir are mos; <'01n111onlJ' used in Gondar IOH:n ... '£1!1iopict The cholesteroi estimation .. ~·as done h)· measuring 1}1e • absorbance on .<JP65 lif,,._J•'f.,· .\ftt:'clrc111'1010"11:1f!r u.\inx l.ieberman-Burchunl reaction 01 640111n, T71e cholestero! contents were found CIS Shula b1111er f]6.'.133 ± (1.257 mg/JO(! gJ. Yadot bu/fer (25299ti±1).217 mg1!1JO gJ nnd .~foma pasteurized butter 1::.'1.1.670 ± a.436 mgi/00 g;. Ferner ' . (128.f:IO J. U.266 mg.'W0g). A_limba (123.1)}0 = 0.216 mg!/00 gj and Blnjig 1216.647 = 0.54i mg/ JOI) g; respectivelv 7J1e Cholestero! content for Retm« and Row margarine were found (210 543 1' 0. I IO mf?i/00 xi and COfi.4f>? + 0.617 mgi!O!J l!J respectively. T11e cholcstero! ~ 1.:011/onl fi»: 11eKdubh• Khee wet.\ 131 . ./3~ - {l. /% mg!/()(1 g (or S/:11,Ji f!,gil 011d 89 ::30 .L O . ./JIJ margarine f8. I.SJ -r 0:102 mg KOT/lg. IJ.579 0.003 nreq!~g) and lower in observed Sheno lego rt 70.5 + 0.00:. mg KOl!tx. !.203 - O.fi/)6 m•·qilc!!j respectively. 111e Saponiticauo» value was l:ighe>I it: Sholu butter fZ./7.()66 .l 0.1 JI mg KOH!gj and towe« in Sneno tega ghee (f·S7 703 .L () 526 mg KOl-flgJ There is 1w need to eat chotrsterot from diet. As none of the samples analyzed 11·u~· found to contain no eoruents of cholesterol. there is a risk oj.cleve!opJng curdiovuscnlar diseases. Thr.• \"'->getahlt! ghite contains 111iu.·l1 le . .,S cholesterol as compared ro margarin« and buuer. Thus, suggcs1illg that though the buuer and margarine samples yielded /1ig.l1es1 vegetable ghee are betterfor lwm(m consumption in tams ofil1dr cholesterol level <111d phvstcochemicai properties T/111s. rlleir consumption b>' 1hf! human beings would be saf" and Keywords: Atheroscterosis, Butter, Vegetable gbce. Margarine. Cholesterol, Liebermann- Hurchard text, CJ1a;-1li1y parametcr-, and l lV-\'io,;ihlc '-'flCClr.)SC.Opy ' m;tf./(JIJ g for She•10 Eega. Sl1ola butler showed the higher acld value 0./. 792 J. (l.'JJ5 mg K()///~; (111(/ peroxid« value (llS.579 - (J_i)(15 1neqlkgJ compare l(> the IOl\'fS( "ntue observed in Blaj1g home made butter 14 . ./IJ ± 0.07./ "'g KOH'g; and (2.0lh = 0.01.J meqikf!J respect.valy. viii