Plectranthus edulis is an ancient and endemic Ethiopian tuber crop. It is widely distributed in Asia, Australia and other African countries. In this study, the concentration of eight essential (Ca, Mg, K, Zn, Cu, Mn, Cr and Ni) and two non-essential (Cd and Pb) mineral nutrients in the digested plectranthus edulis samples collected from six sampling sites in Awi Zone, Ethiopia were quantified using ICP - OES. 0.5 g of oven dried plectranthus edulis sample digested using acid mixture of HNO3 (69-72%) and HClO4 (70%) in a volume ratio of 3:2 at 120 0C for 3 h. The procedure was validated using instrument calibration and to evaluate the linearity of the established calibration curves, regression analysis was used. The procedure was validated by calculating Method detection limit and limit of quantitation and it was checked by spiking experiments and the recovery value ranges from 87 to 117%. The mean concentration (mg/kg dry weight basis) ranges of each metal in the sample were as follows K (1,599 – 1,830), Mg (243 – 951), Ca (138 – 683), Cr (1.37 – 28.33), Ni (0.92 – 20.17), Pb (0.97 – 14.9), Zn (2.77 – 21.23), Mn (0.08 – 10.23) and Cu (3.13 – 6.50). Among the analyzed metals K was found to be the highest metals determined in the samples. However, cadmium was not detected in plectranthus edulis tuber samples of all sites. Ni and Cr were not detected in the samples of Banja in both sites (lideta and quancha) and Ankesh while the rest metals were detected in plectranthus edulis samples Key words: plectranthu edulis, Essential mineral nutrients, Non-essential mineral nutrients and ICP – OES.