Prevalence and Antimicrobial Susceptibility Patterns of Bacterial Uropathogen Isolated from Patients At Debre Markos Referral Hospital

Enbakum, Menelik

dc.contributor.author	Enbakum, Menelik
dc.date.accessioned	2018-01-10T10:46:44Z
dc.date.available	2018-01-10T10:46:44Z
dc.date.issued	2018-01-10
dc.identifier.uri	http://hdl.handle.net/123456789/8440
dc.description.abstract	Urinary tract infection (UTI) remains a worldwide therapeutic problem, not only as a nosocomial disease but also as a community-acquired infection. Antibiotic resistance of urinary tract pathogens has increased worldwide. Infectious Diseases Society of America (IDSA) recently recommended that each hospital should determine the locally establish mechanisms to resistance rates among uropathogens. The aim of this study was to determine the prevalence of the bacterial agents that cause urinary tract infections and their antimicrobial sensitivity pattern against various types of antimicrobial agents used for treating urinary tract infections. A pre-designed and structured questionnaire was used for the collection of data on socio-demographic characteristics. Uro-pathogens were identified by standard methods and tested for antibiotics susceptibility. Eighty eight urine specimens from patients with symptoms of UTI) were screened for the presence of significant bacteruria from November to June 2014. Bacteriological screening of catheterized urine and clean catch mid-stream urine revealed that 6/10 (60%) and 21/78 (27%) had significant bacteriuria, respectively (P<0.05). Out of 88 cases, 27 (30.7%) were positive for significant bacteria, out of which the majority of the bacteria were isolated from female 23 (85.2%) while the remaining was from male 4 (14.8%). In the present study Escherichia coli 11 (40.7%) was the predominant bacteria isolated. Staphylococcus aureus 9 (33.3%) was the second common organism followed by Klebseilla spp. 3 (11.1%). Escherichia coli and Staphylococcus aureus infections were more prevalent in the age groups (21- 60 years). This study revealed high (30.7%) prevalence of UTIs and most bacterial isolates were resistant to ampicillin and amoxycillin. Catheterization and preoperative antibiotic prophylaxis were found to be the risk factors for UTIs. The rate of single and multiple drug resistance was (7%) and (63%) respectively.The most common isolated bacteria from urinary tract infections were E. coli and the most effective antimicrobial agents were ciprofloxacin, gentamicin (for gram negative bacteria) and nitrofurantoin. Available strategies should be designed to reduce the prevalence of UTIs and drug resistance pattern. Keywords: Antimicrobial susceptibility, bacteria, urinary tract infection.	en_US
dc.language.iso	en_US	en_US
dc.subject	biology	en_US
dc.title	Prevalence and Antimicrobial Susceptibility Patterns of Bacterial Uropathogen Isolated from Patients At Debre Markos Referral Hospital	en_US
dc.type	Thesis	en_US