Trafficking in human beings, especially women and girls, is not new. Historically it has taken many forms, but in the context of globalization, has acquired shocking new dimensions. It is a complex, multifaceted phenomenon involving multiple stakeholders at the institutional and commercial level. As human trafficking is the global issue Kemissie is also one of the towns in Amhara Region which is highly affected by this problem. So that, the main aim of this study is to examine the causes and consequences of human trafficking in Kemissie Town. This research is done with the specific objectives of identifying, the major causes of human trafficking, to identify the major facilitating factors, to explore the consequence and to examine the transit and the major destination areas. And also to be recommended some possible solution for the problem. The research has employed a qualitative research method and snow ball purposive sampling was used in selecting the research participants. The study has used different tools during data gathering that include interview, focus group discussion and document analysis. This study shows even if there are some economic and social problems that cause human trafficking but the main cause is that the majority of youth and the community had positive attitudes towards migration and believe it to be the best solution to improve their ways of life. Lack of awareness, the positive attitude of the people towards human trafficking and false information made by brokers are the major factors drawing women and youths into human trafficking. Political pressure, religious attitude and culture of migration is also another cause identified by the researcher. This study revealed a variety of health, economical, social and political problems encountered by victims of human trafficking. According to the informants, the problems include lack of access to water, food, shelter, constant rapes, inadequate rest, psychological abuse, depression, inadequate sleep, sexual abuse, death, torturer, salary deprivations, work overloaded and the crackdown of family bondage are the common consequences revealed by the researcher. Generally the challenges that trafficked people faces started from the recruitment process and continued up to the destination countries.