Now a days the effect of Greenhouse gas emission is the major issue around the globe because of its contribution for global warming. To reduce the effect of global warming, different scientists have been studying renewable alternative energy source like wind energy. As a part of this we are interested to study the potential of wind energy around Amhara region in Lake Tana Basin. The purpose of this study is therefore to analyses wind speed characteristics and wind power potential of Bahirdar, Debremarkos, Debretabor and Debark district using statistical two Weibull parameters. The parameter of the Weibull distribution is used for the calculation of average speed, standard deviation and power density based on the Empirical method. The data measured in 24 hour time series average wind speed over a period of ten years (2007 - 2016) at two meter height is obtained from Bahirdar Meteorology station. The outcome show that the shape parameter (k) ranges from 2.85 to 7.74 in Bahirdar, 3.9 to 12 in Debremarkos, 5.28 to 10.43 in Debretabor and 3.32 to 6.29 in Debark district while the scale parameter (c) varies from 0.72 to 1.35 m/s in Bahirdar, 1.35 to 1.53 m/s in Debremarkos, 0.8 to 1.4 m/s in Debretabor and 1.66 to 1.83 m/s in Debark district. Comparatively Debark district have good wind potential than Bahirdar, Debretabor and Debremarkos districts. In view of these study shows that, wind potential of those districts are not sufficient for wind energy. Keywords: wind speed, statistical analysis, wind power, Weibull parameters