Renewable energy is considered to be one of the pivotal wedges that can combat global warming and stabilize the climate, through the reduction of carbon dioxide emissions. Solar energy is one of the most important renewable energy sources. In this study we assessed the potential of solar radiation over the Amhara region of Tana basin using the daily sunshine hours and temperature data of Bahir Dar (1985-2016), Debre Markoss, Debre Tabor and Gondar (2007-2016) obtained from National Meteorological Agency of Ethiopia. Using these data we calculate the average monthly and annually global solar radiation by using both the Angstrom-Prescott and Hargreaves empirical models. From the result, the monthly average solar radiations of the four stations calculate using the two models is maximum at spring and minimum in summer season. It also has maximum value in November. Hargreaves model gives large output of radiation than Angstrom model. In both models Bahir Dar has maximum monthly and annually radiation. So it better to install PV cell in Bahir Dar to generate more electric power.