Abstract:
The discoveries of metal complex drugs are found to be more effective than parent drugs to
overcome the microbial resistance towards antibiotics. This work involves synthesis, structural
investigation and assessment of antibacterial activities of free 1, 10-phenanthroline, 2,2-
bipyridine and metal complexes. The complexes were characterized by using different
physicochemical and spectroscopic techniques such as FT-IR, UV-Vis and ICP-OES. The results
indicated that the copper ion coordinated to phenanthroline and 2, 2-bipyridine ligands to give
square pyramidal geometry. The complexes and ligands have been screened for in-vitro
antibacterial activity against two gram positive and two gram negative bacteria. The antibacterial
screening showed that the copper (II) complexes have reduced activity towards the various
bacteria when compared with the free ligand phenanthroline. However, copper (II) complexes
have better antibacterial activity compared with the free ligand 2, 2-bipyridine.
Keywords: Cu (II) complexes, 1, 10-phenanthroline, 2, 2-bipyridine, antibacterial activity