dc.description.abstract |
Typhoid fever, which is caused by the gram-negative bacterium Salmonella typhi, is still a
significant public health issue on a global scale. It is a major source of food-borne disease
worldwide, and the spread of antimicrobial-resistant strains is becoming a rising concern. Travel
to endemic areas, poor hygiene habits, poor sanitation conditions, proximity to flying insects
feeding on faeces, contact with someone who recently suffered from typhoid fever, recent use of
antibiotics, immunosuppressive illnesses, crowded housing, consumption of raw fruits and
vegetables contaminated with sewage, are all risk factors for typhoid fever. The primary goal of
this study was to determine the prevalence of typhoid fever, antimicrobial resistance patterns and
associated risk factors among febrile patients at Felege Hiwot comprehensive specialized referral
hospital from January to March 2023. A cross-sectional study was carried out on 403 febrile
patients who were selected using systematic random sample techniques. Face-to-face interviews
with pretested structured questionnaires were used to collect data. Stool specimens were
collected, cultured, and biochemical and antimicrobial susceptibility testing was performed using
the Kirby-Bauer disc diffusion method with the assistance of two competent laboratory workers.
SPSS version 25 was used to enter and analyse the data. Binary logistic regression was done to
determine the strength of association between dependent variables and possible risk factors.
Variables with a p value of less than 0.25 during Univariate logistic regression analysis were
selected for multivariate analysis. A p-value of less than 0.05 was used to indicate statistical
significance. The overall prevalence of typhoid fever was 4.5% (18/403). Factors like eating raw
vegetable and fruits [AOR =9.88; 95% CI: (1.285–75.990, p = 0.028)]; eating street food [AOR
=8.57; 95% CI: (1.279–57.398, p = 0.027)], and drinking raw milk [AOR =7.58; 95% CI:
(1.102–52.207, p = 0.040)] were statistically significant associated with the occurrence of
typhoid fever. The majority of Salmonella typhi isolates were responsive to Ciprofloxacin but
resistant to Ampicillin and Cotrimoxazole. Based on these findings, not drinking raw milk
improving sanitation and hygiene practices, and limiting intake of microbially contaminated food
can help lower the occurrence of typhoid fever.
Keywords: - typhoid fever, Salmonella typhi, antimicrobial resistance patterns, associated risk
factors, prevalence, |
en_US |