Application of Copula on Time to Last Stage of Left and Right Breast Cancer of Patients at Felege Hiwot Comprehensive Specialized Hospital, Bahir Dar, Ethiopia

Alehegne Adamu

dc.contributor.author	Alehegne Adamu
dc.date.accessioned	2022-08-19T07:40:18Z
dc.date.available	2022-08-19T07:40:18Z
dc.date.issued	2022-08-13
dc.identifier.uri	http://ir.bdu.edu.et/handle/123456789/14032
dc.description.abstract	Background: Breast cancer is a type of malignant tumor that starts in the breast cells and commonly occurs in women than men. Breast cancer mostly occurs in the left breast rather than the right breast and studies show that there is a significant associ ation between time to left and right breast cancer laterally. As far as our knowledge is concerned, researchers didn’t see the dependency between left and right last stage breast cancer patients. Objectives: The main objective of this study was to compare different marginal mod els with copula families for time to last stage of left and right side breast cancer patients and explore whether there was a statistical dependency between time to left and right last stage breast cancer. Moreover, to identify the risk factors of last stage breast cancer of patients. Methods: A retrospective study design was used to collect relevant data on time to events of last stage breast cancer patients. A total of 516 patients were included in this study. In this thesis, mainly nine different copula-based bivariate survival models were employed. Two-step estimation method was used to estimate the marginal dis tributions and copula parameter. The dependence between the time to right and left last stage breast cancer of the patient was quantified using the copula parameter, and the effect of covariates were modeled using the parametric marginal survival model. Results: Of 516 patients, 59 (11.4%), 55 (10.7%), 146 (28.3%) patients only right, only left breasts, and both breasts were at the last stage, respectively. The Weibull marginal distribution with the Clayton copula model fit the last stage breast cancer dataset. The dependence between time to last stage of right and left breast cancer of female patients is found to be 0.189. Conclusion: Being Hypertensive, older patient, positive status of anemia, who resides in rural and chemotherapy treatment of breast cancer disease were the risk factors that leads to last stage breast cancer. In conclusion, there is a statistical dependency be tween the time to right and left last stage breast cancer of the patients. Keywords: Bivariate events, abnormal cell, Weibull-Clayton, Kendall’s dependenc	en_US
dc.language.iso	en_US	en_US
dc.subject	Statistics	en_US
dc.title	Application of Copula on Time to Last Stage of Left and Right Breast Cancer of Patients at Felege Hiwot Comprehensive Specialized Hospital, Bahir Dar, Ethiopia	en_US
dc.type	Thesis	en_US