VOLTAMMETRIC DETERMINATION OF ASPIRIN IN TABLET FORMULATION USING NOVEL POLY(DIAQUABIS(1,10- PHENANTHROLINE)COPPER(II)CHLORIDE) MODIFIED GLASSY  CARBON ELECTRODE

MEBRIE, ASNAKECH

dc.contributor.author	MEBRIE, ASNAKECH
dc.date.accessioned	2021-08-06T07:57:27Z
dc.date.available	2021-08-06T07:57:27Z
dc.date.issued	2021-08-06
dc.identifier.uri	http://ir.bdu.edu.et/handle/123456789/12311
dc.description.abstract	In this study, glassy carbon electrode (GCE) modified potentiodynamically by poly(diaquabis(1,10-phenanthroline)copper(II)chloride) (poly(A2P2CuC)) is reported for the detection of aspirin in tablet formulation. The improved effective electrode surface area calculated from the effect of scan rate on current response for Fe(CN)6] 3-/4- and the charge transfer resistance result from electrochemical impedance data confirmed surface modification of the glassy carbon electrode by a conductive poly(A2P2CuC) film. APPEARANCE OF AN OXIDATIVE PEAK WITHOUT A REDUCTIVE PEAK IN THE REVERSE SCAN DIRECTION AT poly(A2P2CuC/GCE showed the irreversibility of the electrochemical oxidation of ASA at the electrode. A better correlation coefficient for the dependence of peak current on the square root of scan rate (R2=0.9983) than the scan rate (R2=0.9612) indicated that the oxidation of ASA at poly(A2P2CuC)/GCE was predominantly diffusion mass transport controlled. Under optimized PBS of pH 5.5, and square wave parameters, square wave oxidative peak current response of the modified electrode showed linear dependence on the concentration in the range 1-200 µM of associated %RSD values below 3.7% for (n=3) with a correlation coefficient (R2 ), limit of detection, and limit of quantification of 0.9986, 0.039 µM, and 0.13 µM, respectively. Recovery was found in the range 96.5-100.5% with %RSD value of below 1.9% for (n=3), and interference recovery in the range 97.2-103.4% in the presence of 50-200% of uric acid, ascorbic acid, and glucose as potential interferents validated the applicability of the developed method for determination of ASA content of tablet formulation. The aspirin level in the studied tablet was ranged between 99.4 to 101.5% of their labeled values by the manufacturer with %RSD value of below 2.6% confirming the efficiency of the method for ASA determination in real samples. The present method had a better performance for determination of aspirin in tablet formulation as compared with recently reported voltammetric methods, due to its requirement of simple electrode modification step, provides the least limit of detection, and reasonably wider linear dynamic range.	en_US
dc.language.iso	en	en_US
dc.subject	Chemistry	en_US
dc.title	VOLTAMMETRIC DETERMINATION OF ASPIRIN IN TABLET FORMULATION USING NOVEL POLY(DIAQUABIS(1,10- PHENANTHROLINE)COPPER(II)CHLORIDE) MODIFIED GLASSY CARBON ELECTRODE	en_US
dc.type	Thesis	en_US