PREDICTORS OF AVERAGE SEIZURE ATTACKS AND TIME TO SEIZURE FREEDOM IN EPILEPTIC ADULT PATIENTS AT FELEGE HIWOT COMPREHENSIVE SPECIALIZED REFERRAL HOSPITAL: SEPARATE AND JOINT MODEL APPLICATION

YIRGA, MEKONNEN

dc.contributor.author	YIRGA, MEKONNEN
dc.date.accessioned	2020-09-08T11:44:54Z
dc.date.available	2020-09-08T11:44:54Z
dc.date.issued	2020-09-07
dc.identifier.uri	http://hdl.handle.net/123456789/11201
dc.description.abstract	ABSTRACT Back ground: Epilepsy seizure is one of the most common and serious brain disorders and affects more than 50 million people in the world, approximately 10 million people annually in sub-Saharan Africa. Also in Ethiopia, affects about 29.5 per 1000 population. It has serious physical, psychological, social and economic consequences by reducing patients’ quality of life. The main objective of this study was predictors of longitudinal six month average seizure attacks and time to seizure freedom of epileptic patients using separate and joint model application. Method: A retrospective cohort study design was conducted from 131 systematic selected epileptic patients in Neurologic clinic at Felege Hiwot Comprehensive Specialized Referral Hospital (FHCSRH), Bahir dar, Ethiopia. The data was collected primarily and secondarily using interview and patient charts under the follow-up period between 1st November 2014 up to 31 December 2019. Graphical exploratory analysis using Kaplan Meier, profile plots and a linear mixed effects model for the longitudinal six month average seizure attacks, a semi-parametric Cox proportional hazards model for the time-to-event of seizure freedom and joint model of the two responses linked by shared random effects was done. Result: Among 131 of epileptic patients 73(55.7%) of epileptic patients were experiencing seizure free during the follow up time. The overall mean and median estimated survival time of epileptic patients under the study was 41.721 and 42 months respectively. Estimates of the association parameter (α=-5.3414,P<0.0001) in the joint analysis was highly significant and model parameters were estimated with lower standard errors, provides evidence of joint model selection. Seizure freedom period is prolonged in epileptic patients with higher seizure attacks. Conclusion: Joint model was performed better fit for this study and gives valid inferences for the parameters. Lately coming to diagnosis, comorbide, being mental disable, head injured, and patients medicated with payments were increase the average seizure attacks and prolonged the period of seizure freedom. While believing to cure and high adherent patients more likely to experience seizure freedom. It would be better if a health professionals, community and family members of patient with epileptic seizures put a great effort on enhancing adherence and health	en_US
dc.language.iso	en_US	en_US
dc.subject	STATISTICS	en_US
dc.title	PREDICTORS OF AVERAGE SEIZURE ATTACKS AND TIME TO SEIZURE FREEDOM IN EPILEPTIC ADULT PATIENTS AT FELEGE HIWOT COMPREHENSIVE SPECIALIZED REFERRAL HOSPITAL: SEPARATE AND JOINT MODEL APPLICATION	en_US
dc.type	Thesis	en_US