Abstract Introduction: Ethiopia is one of the most populous countries in Africa and with the highest number of new HIV/AIDS infections. So, the main objectives of this study were to demonstrate the joint predictors of the modern contraceptive use and knowledge of HIV/AIDS prevention of women aged 15-49 across the clusters, in Ethiopia. Method: This study considered a weighted sample of 10,223 married women aged from 15-49 years which extracted from the (2016) EDHS data. The Ethiopian DHS data utilized multistage sampling by using two-stage sampling design to select the sample from the population. In this study, the separate multilevel modelling for the each outcomes and bivariate model were used. Result: The descriptive statistics revealed that about 35.25% of women use modern contraceptive methods and 45.42% of women know about HIV prevention. The estimated association parameter in bivariate multilevel was 0.129 which is statistically significant (P-value < 0.001). This indicated that there is evidence of the association between the use of modern contraceptive methods and knowledge of HIV prevention among pairs of women in the same clusters. The bivariate multilevel logistic regression model was performed better than a separate model based on a lower standard error and efficient parameter estimates. It was found that about 45.02%, 39.59% of the variation in modern contraceptive use, and knowing about HIV prevention at the clusters level among women is explained with predictors, respectively. Conclusion: This study revealed that the use of a modern contraceptive method and knowledge of HIV prevention among women varies across the clusters or communities. The predictors a visiting health facility, wealth index, media exposure, religion, place of residence, and contextual region were significantly associated with the two responses of women. The result indicated that women who use the modern contraceptive method were more likely to know about HIV prevention. This study revealed the use of a modern contraceptive method has a spillover effect on knowledge of HIV prevention. The knowledge of HIVAIDS prevention seemed to be influenced by education was contributed to one use of modern contraceptives. So, the integration of the two programs can have advantages in terms of clinical benefit, cost, and care to seek individual. So, the intervention measures should be undertaken by the concerned body at the community level