Now a day, Construction works are taking place on a huge scale all over the world and the need for construction materials is increasing day by day. Cement is one of the most ingredients of concrete but is the most expensive and environmentally unfriendly material. In this study, maize cob ash is used as a partial replacement of cement in concrete production; the compressive strength and workability of concrete with and without maize cob ash were investigated. Furthermore, the normal consistency and setting time of the MCA-OPC blended paste were analyzed and the results revealed that the normal consistency increased as MCA increased and both initial and final setting times increased with increased the MCA replacement level. The pozzolanic property of maize cob ash was also checked by determining the elemental oxide compositions. Based on ASTM C 618 Maize cob ash was classified into class N pozzolana. The concrete cubes were prepared in the sixth series of concrete mixes based on the conventional mix techniques; from which the two concrete mixes were used for reference mixes, which were prepared from OPC and PPC cement without replacement of maize cob ash. The remaining four concrete mixes were prepared by partial replacement of ordinary Portland cement (OPC) with different percentages of MCA: 5%, 10%, 15%, and 20% to attain a specified compressive strength of 25 Mpa with water-cement ratio of 0.49 and 360kg/m3 cement content. The concrete cubes were cured using curing tanks in the laboratory until the compressive strength test was tested at the age of 3rd, 7th, 28th and 56th days. The result of the compressive strength test showed, up to 10% replacement of maize cob ash with ordinary Portland cement achieves the target mean strength of 33.5Mpa on 28th days. However, the compressive strength decreases with an increasing percentage of maize cob ash in concrete. As the replacement level of cement with MCA increased, the densities of concrete cubes were decreased. The study examines the fresh and hardened properties concrete with and without maize cob ash, and its economic advantage and saving of natural raw materials to sustain concrete production.