The growth of the Ethiopian economy stimulates the expansion of private and public construction industry. Construction materials demand increases with the growth of infrastructures and private building construction. Cement is one of the most commonly used construction materials to produce concrete. The environmental degradation because of the exploration of cement forming clinker materials highly affects the sustainability of ecology. Utilization of the locally available waste material is one of the most important way to reduce the environmental degradation due to cement production and affording cheap and sustainable cementitious material. The study was aiming to investigate the effect of partial replacement of cement by cattle bone ash in concrete property. Complete silicate analysis of cattle bone ash shows that the material has high calcium oxide content (43.26%) which is the major oxide compound of cement. This study was conducted by using locally available concrete making materials in Bahir Dar city. A C-25 concrete grade was selected for this study. The Normal consistency, setting time, soundness of cement paste, slump, compressive strength and density of concrete tests are done with (0%), 5%, 10%, 15% and 20% cement replacement with cattle bone ash. The compressive strength of concrete was done by curing 15cmx15cmx15cm cube concrete specimens underwater for 3, 7, 28 and 56 days. The normal consistency of the cement paste increases as the percentage of the cattle bone ash increases in the paste attributed to high water absorption of CBA than OPC. The initial and final setting time of cement paste increase as the percentage of replacement of cement with bone ash, because of the presence of P2O5 in CBA which exhibits retarding setting time. The slump of concrete decreases at 0% to 10% CBA mix and increases in 15% to 20% CBA mix. From the results, the partial replacement of Ordinary Portland Cement with bone ash shows a gradual decrease of the compressive strength of concrete due to low formation of C3S in CBA blended cement. The concrete density decreases as the percentage of bone ash increases due to low unit weight of bone ash compared to Ordinary Portland Cement. The use of cattle bone waste as an additive or supplementary cementing material production has vital importance to produce low-cost concrete and helps to conserve materials needed for cement production.