Quality Management Systems (QMS) makes a powerful contribution toward the competitiveness of corporations. However, the evidence of QMS in Amhara Pipe factory (APF) indicates that focus only their certification. Therefore, the implementation of ISO 9001 certification in APF does not replicate the presence of deep-rooted operational practices and strategies wanted for ensuring the final delivery of a proper operated QMS. Consequently, it’s had information barrier and increases bureaucracy. The goal of this research is to integrate the Quality Management System (QMS) implementation based on Manufacturing Culture to improve the QMS efficiency in APF. The review of the literature found that there is a significant correlation between the organizational culture of a company and the quality performance of manufacturing. Although research in this area has involved many researchers, there is no critical mass of information specifically related to the situation of the industry. The studies based on contemporary perspectives of the characteristics of the organizational culture that use the Organizational Culture Assessment Instrument (OCAI) of Cameron and Quinn and their relationship with the contractor's ISO 9001 practices have not been previously carried out. Therefore, the culture profiles in APF were investigated, along with the current implementation of ISO 9001 and its performance during the implementation of QMS, since the information in these areas influences the low performance and low levels of competitiveness of the manufacturing industry. The methodology of the study is based on a mixed methodology of quantitative and qualitative approaches that was used to collect relevant data and information associated with the current status of the QMS and the organizational practices of cultural problems within the APF. The questionnaire surveys were distributed to the selected APF staff, in order to collect responses designed to examine the effectiveness of the implementation of their QMS. The results of the questionnaire survey supported the development of an Implementation Framework for the improvement of the Quality Management System based on Culture, designed to assist the APF. Identify some typical barriers associated with the impact in the biggest implementation area of effective QMS, such as; Integration of the framework to implement the quality management system based on culture to improve the performance of the manufacturing industry, cultural Quality Management System (QMS) Implementation Based on Manufacturing Culture III changes in the manufacturing organization, communicate the quality objective, the organizational role, responsibility and authority, the management review and non-conformities and corrective actions. This study shows that the Quality Management System (QMS) implementation based on manufacturing culture is a powerful tool for better efficiency and allows manufacturing industry to continuous improvement.