Water security is one of the global indicators in sustainable development goals, which becomes the cross-cutting issue worldwide. Studies have been performed at global, national, and city levels to assess the water security issues. Since assessment of water security at domestic scale has not been done yet in developing countries like Ethiopia, it is essential to develop an appropriate framework for the assessment of domestic water security at the city scale and apply it for urban cities of Ethiopia. This study therefore aimed at developing the domestic water security assessment framework for cities in Ethiopia. In this study, the concept of domestic water security is defined as the status of a person to access safe quality and enough quantity of water for domestic use, safely managed sanitation and hygiene facilities with an affordable price. The developed framework comprises of three dimensions: water supply, sanitation and hygiene; eleven indicators: water supply availability, water supply quality, water supply coverage, water loss, water supply affordability, sanitation coverage, sanitation management, affordability of sanitation system, coverage of hygienic facilities, and implementation of hygienic practices and affordability of hygienic services and fifteen variables: per capita fresh water availability, per capita water consumption, water supply continuity, pressure head adequacy, proportion of served population in piped water supply system, proportion of safe drinking water, unaccounted for water in the system, proportion of households that can afford the water tariff, proportion of population using improved sanitation services, proportion of population use grey water soak pit, proportion of population using safely managed sanitation system, percentage of population that can afford cost of sanitation services, proportion of population using proper hygienic facilities, proportion of diarrheal case under age five, and proportion of households that can afford cost of hygienic services. These indicators were defined using the driving forces, pressure, state, impact and response (DPSIR) approach. The variables of the indicators were defined by specific, measurable, attainable, relevant and time-bound (SMART) criteria were used to identify and select the composite of the appropriate indicators and variables to achieve. Analytical hierarchy process (AHP) and equal weighting methods were used to compute an index by giving different and equal weighting factors for variables, indicators and dimensions respectively. The developed framework was applied for Bahir Dar city to quantify its domestic water security index with the available data for the year 2017/18. Generally, Bahir Dar city is found under medium (2.8) domestic water security status with high (3.41), medium (2.29) and very low (1.0) indices of water supply, sanitation and hygiene dimensions respectively