Background: Mostly, food insecurity is expected in rural households. But it is considerable in urban areas due to many factors. Yet this has been hardly recognized in the study area. Therefore, this study was done to assess the level of household food insecurity and its determinant factors in Bure town, Northwest Ethiopia, 2019 G.C. Methods: A community based cross-sectional study was conducted with 512 households selected from the town by systematic sampling technique. Data were collected using pretested structured questionnaire through interviewing household heads. The magnitude of household food insecurity was assessed using descriptive statistics. Ordinal logistic regression analysis was used to identify determinant factors of household food insecurity. Odds ratio was used as a measure of strength of association with a 95% confidence interval. Variables with p-value <0.05 were considered statistically significant. Results: About 69% (95% CI: 64.9, 73) of households were food secure 31% (95% CI: 27, 35.1) households were food insecure with mild, moderate and severe food insecurity level of 16% (95% CI: 12.8, 19.3), 10.1% (95% CI: 7.5, 13), 4.9% (95% CI: 3, 6.9) respectively. Greater than two dependent household members (POR = 5.1, 95% CI: 2.61, 10.09), occupation of household head-daily wage (POR = 4.6, 95 % CI: 1.33, 7.99), occupation of mother-self-employed (POR = 5.4, 95 % CI: 2.41, 12.08), average monthly income ≤1,000 ETB (POR= 20.3, 95% CI: 15.93, 25.35), average monthly income 1,0011900 ETB (POR= 3.24, 95% CI:1.53, 6.89), average monthly food expenditure ≤700 ETB (POR= 8.6, 95% CI: 2.51, 11.46), average monthly food expenditure 701-1,200 ETB (POR= 5.5, 95% CI: 2.19, 13.85) were significant predictors of household food insecurity. Conclusion and Recommendation: Household food insecurity was high in the study area compared with the national estimate. Therefore, action needed on increasing access to food by increasing income, designing household food security strategies, creating job opportunities, strengthening family planning service and increasing saving practice to improve household food security