Wine is an alcoholic beverage which contains inorganic as well as organic components. The quality of wine depends on the concentration of these components. In this study, after digestion of wine sample and preparation of standard KMnO4, the selected metals and tannins were determined in the six Awash brands of Ethiopian wines using ICP – OES and Titrimetric method respectively. The result indicates, all Awash wine brands were rich by macro metals (K, Na, Ca, Mg). From all trace metals, Fe was the most abundant in both Gebeta Red and Gebeta White, but least in Axumite Red. Pb was not detected in three Awash brands (Gouder red, Axumite Red and Kemila white), but Gebeta red, Gebeta white and Awash Tekishino were contain Pb. Cd was not detected in all six Awash wines. The level of Cr in Gouder red was below detection limit, but Kemila white has the highest content of Cr than all brands. Awash wine brand also contain tannin in the range of 0.021-0.032% with mean value of 0.0451%. The one way ANOVA for most metals in Awash brand were significant difference with (p <0.05), Na was significantly different in all wine brands and some metals were not significantly different in each brands with (p> 0.05). Comparing the level of tannin in Red wines with white wines, it was significantly different (p< 0.05), but not significant with another some red wines. This indicates that, the level of tannin in red wine was more concentrated than in white wines. Keywords: Metals, Tannin, wine, ICP–OES and Titrimetric Method.