Abstract:
In this study the electrochemical behavior of GlyCPE was compared with bare CPE for the determination of PCT using CV and DPSV. After cyclic voltammetric investigation of the electrochemical behavior of paracetamol and dependence of peak current on scan rate and pH; differential pulse stripping voltammetric method based on glycine modified carbon paste electrode was developed for direct determination of paracetamol in pharmaceutical tablet samples. In contrast to the peak potential at the unmodified electrode, enhancement of the oxidative peak at a lower potential at the modified electrode indicated a catalytic property of the modifier towards paracetamol oxidation. While the observed peak potential shift with scan rate confirmed the irreversibility of the reaction, comparable correlation coefficients for the dependence of peak current of square root of scan rate and the slop of log ⱱ versus log Ipa indicated that the irreversible oxidation reaction was diffusion controlled. The peak current response of the developed method showed a linear dependence on the paracetamol concentration in the range 5 to 1000 μM. The recoveries from 90 to 106%, wide dynamic range, low limit of detection (0.01 μM), and limit of quantification (0.04 μM). Good recovery results for spiked PCT in tablet samples and selective determination of PCT in tablet formulations in the presence of selected potential interferents such as ascorbic acid confirmed the potential applicability of the developed method for the determination of PCT in real samples. Finally, the proposed methods were applied for paracetamol determination in three brands of pharmaceutical tablet samples such as Julphar aldol, Panadol adva, and Para denk.
Keywords: paracetamol, tablet formation samples, glycine modified carbon paste electrode, cyclic voltammetry, differential pulse stripping voltammetry.