Abstract This study W(;lS conducted to assess the prevalence of Plasmodium species infection and proper utilization pattern of insecticide treated mosquito nets in Merawi Zuria Woreda, West Gojjam from October 2010 to January 2011. The study consisted of 403 subjects selected from four kebeles. Both thick and thin films were prepared and stained using parasitological standard procedures and examined under a microscope. Questionnaires were prepared and distributed to get information on insecticide treated mosquito net utilization. Out of 403 individuals examined for Plasmodium infection, 130 (32.3%) subjects were found to be positive for malaria parasites. The overall prevalence of Plasmodium was 32.3% in which the prevalence of P falciparum was found to be the highest (52.3%) followed by P vivax (37.7%). A mixed infection of P falciparum and P vivax malaria was higher (14.6%) in Kudime and lower (3%) in Enashenifalen Kebeles. Out of 56 male individuals, 30 (44.1%) were infected by Pfalciparum, 22 (44.8%) by P vivax, and 4 (30.1%) by a mixed infection of Pfalciparum and P vivax malaria. 39.7% of non pregnant women were infected by P. falciparum, 36.7% by P vivax and 30.8% by mixed infection of P falciparum and P vivax. Pregnant women were highly infected by a mixed infection of P falciparum and P vivax (38.5%) than males and non-pregnant women (30.8%). There was an association (P=0.023) between living residence, sex, and age of the individuals with prevalence of Plasmodium species infection. Children below 5 years were highly infected by P falciparum • and P vivax ~ith malaria prevalence rates of 29.4% and 20.6%, respectively. Possession of .,, . insecticide treated mosquito nets was high but, there was a gap in its coverage and utilization. In th;' study area the majority of the residents ~ceived freely supplied ~ blue and rectangular netybut, not all nets were properly utilized. Educational status, age and occupation I had impact on the utilization pattern of insecticide treated mosquito nets. House structure, absence of bed room and utilization of the nets for another purpose affected the proper utilization of the insecticide treated mosquito nets