http://ir.bdu.edu.et/handle/123456789/1660 2026-08-27T19:24:23Z http://ir.bdu.edu.et/handle/123456789/17087 Treatment Outcome And Associated Factors Of Perforated Peptic Ulcer Disease Patients, At Compreehensive Specialized Hospitals, Bahirdar Ethiopia: A Seven And Half Year Retrospective Review Worku, ; Abebaw Background: Peptic ulcer disease represents a worldwide health problem because of its high mortality and morbidity in up to 30% and 50% of patients, respectively) & economic loss. Perforated peptic ulcer is one of the serious acute complications of peptic ulcer with potential of resulting in bad outcomes. It occurs in 2-10% of patients with ulcer disease and its principal treatment is surgical. There are only few published reports on this big health burden in our country so far. 2026-03-01T00:00:00Z http://ir.bdu.edu.et/handle/123456789/17085 Treatment outcome and associated factors of perforated peptic ulcer disease patients, at compreehensive specialized hospitals, bahirdar ethiopia: a seven and half year retrospective review Worku, Abebaw Background: Peptic ulcer disease represents a worldwide health problem because of its high mortality and morbidity in up to 30% and 50% of patients, respectively) & economic loss. Perforated peptic ulcer is one of the serious acute complications of peptic ulcer with potential of resulting in bad outcomes. It occurs in 2-10% of patients with ulcer disease and its principal treatment is surgical. There are only few published reports on this big health burden in our country so far. 2026-03-27T00:00:00Z http://ir.bdu.edu.et/handle/123456789/15546 Magnitude of Appropriate Use of Surgical Antibiotic Prophylaxis and Associated Factors Among Surgical Operated Patients in Tibebe Ghion Specialized Hospital, Bahirdar, Northwest Ethiopia Mulat, Agalu Excessive and inappropriate use broad spectrum antibiotics for surgical prophylaxis has led to development antimicrobial resistance, reduced treatment efficacy, a rise in morbidity and mortality and increased costs. The aim of this study is to assess magnitude of appropriate use and adherence of antimicrobial usage in surgical prophylaxis to the clinical antibiotics prophylaxis guidelines Objective:To assess magnitude of appropriate use of surgical antibiotic prophylaxis and associated factors among surgical operated patients in Tibebe Ghion Specialized Hospital, Bahirdar city, Ethiopia, 2023 Methods: Hospital based cross-sectional study of all patients operated in general surgery wards in TGSH BahirDar city from January to August 2023 was conducted.Systematic sampling technique by was used and the final sample size for the study was 422.The data was collected using standard check list and using patient’s medical record, inpatient and outpatient registry book, and OR logbook as a source of data. The collected data was entered into SPSS 27 for analysis. Bivariate and multivariate logistic regression was done at p-value 0.05 and model fitness was cheeked using hosmer and lemeshow. Binary regression model was used. The result is presented in tables, charts and graphs. Results: A total of 412 patients medical records were evaluated and out of them 355(86.2%) of cases received prophylactic antibiotics. Among the patients for whom prophylaxis administered, 79(22.3%) of prescriptions were appropriate. Ceftriaxone and metronidazole were most commonly prescribed prophylactic agents in 209(58.9%)The mostcommon reasons for appropriate prophylaxis were dosage, 355(100%), indication, 328(92.4%), duration of administration, 238(67%), choice of antibiotics, 110(31%) and timing of administration, 91(25.6%). Availability of first line prophylactic antibiotics is 16.8 times increased appropriateness of surgical antibiotic prophylaxis use than non-availability at the time of prescription (AOR95%CI=16.834(7.687-36.865, p=0.01). Patients after prostatectomy received prophylactic antibiotics 4.115 times appropriately than patients after cholecystectomy (AOR=4.115(95%CI, 1.404-12.048, p-value=0.010)). Patients for whom thyroidectomy done received SAP 23.255 times appropriately than patients after cholecystectomy (AOR=23.255(95%CI, 2.967-71.428, p value=0.001)) and patients after hernia repair received 48.64times more appropriately than patients after cholecystectomy (AOR=48.64(95%CI, 10.622-222.144, p value=0.000)) Conclusions: Appropriate use of surgical antibiotic prophylaxis is low in surgical wards of TGSH and ceftriaxone and metronidazole were most common prescriptions as surgical prophylaxis. To improve appropriate use, ensure availability of first line antibiotics, provision of continuouseducation and escalation of short-term training of prescribers for appropriate use ofantibiotics and preparation of local surgical antibiotics prophylaxis guidelines and protocols should be considered. Key words: Surgical antibiotic prophylaxis, surgical ward, BahirDar University 2023-11-10T00:00:00Z http://ir.bdu.edu.et/handle/123456789/15545 Perioperative Surgical Management Outcome And Associated Factors Among Patients With Perforated Peptic Ulcer Disease Intertiary Centers, Bahirdar, Ethiopia Bametaw, chalie Background: Perforated peptic ulcer is a life-threatening complication with a high morbidity and mortality. It is the most common indication for emergency operation and remains a significant healthcare problem, which can consume considerable financial resources.Aim of this study is to assessperioperativesurgical management outcome and associated factors among patients with perforated peptic ulcer disease at tertiary hospitals in BahirDar,Ethiopia, in 2023 Methods:Institution based retrospective study designwas conducted to assess perioperative surgical management outcomes of perforated peptic ulcer disease atTibebeGion Specialized Hospital and FelegeHiwot Specialized Hospitalby reviewing a 4 years datafromSeptember 12, 2019 to September 11, 2023. Results:A total of 118 patients with perforated peptic ulcer disease were operated in a 4 yearperiod. Hundred five (105) (89 %) patients were males and 13(11%) were females with 6.8:1 male to female ratio. The mean and median age of patients was 43.09± 15.34 and 42 years respectively. The peak incidence was between 31 and 45 years (33.1%). Most (81.4%) were from rural area.The mean and median duration of presentation onset of symptom were 42.63 ± 27.394 and 30.50 hours respectively. Most(56.8%) present after 24 hours.Themean and median level of GI contamination was found to be1193.64±1058.72 and 800.00 ml respectively. Duodenalperforation was found in 108 (91.5%) patients. The mean size of perforation was 7.32 ±3.44 mm. Graham's patch was the choice of procedure in all cases. Drain was used in 94.9 % of cases.Postoperative complications occurred in 21 (17.8%) patients and 6(5.1%) patients died before discharge while others discharged improved. The most common complications were SSI (6.8%), pneumonia (3.4%) and re-laparotomy (3.4%).Sizeof perforation is associated with overall adverse outcome, (p=0.022) respectively. Conclusion:Perforated PUD is common among young males. Seventy eight percent of our patients have overall favorable outcome and mortality and morbidity is quite acceptable. Size of perforation significantly associated with overall adverse outcome. Keywords:peptic ulcer disease, perforated peptic ulcer disease, outcome, associated factors, prognostic factors 2023-11-10T00:00:00Z