http://ir.bdu.edu.et/handle/123456789/1834 2001-01-13T05:52:59Z 2001-01-13T05:52:59Z Yenework, Zewdu http://ir.bdu.edu.et/handle/123456789/16800 2025-07-28T12:33:26Z 2024-07-01T00:00:00Z

Ron(Iii) Complex With Guanide, Benzoic Acid, And 1, 10-Phenanthroline: Synthesis, Characterization And Antibacterial Activity Study Yenework, Zewdu ron can bind to a range of molecules forming complexes that are suitable for use in various applications. Different ligands could be used to tune the properties of Iron. In this study, three complexes were synthesized from 1,10-phenanthroline (phen) alone as [Fe(phen)(H2O)4]Cl3 and from both 1,10-phenanthroline and benzoic acid (BA) as [Fe(phen)(BA)(H2O)3]Cl3 as well as from phen, BA and guanide (Gu) as [Fe(phen(BA)(Gu)((H2O)2]Cl2. The synthesis was checked using halide test, conductance measurement, spectroscopic (FTIR, Uv-vis) as well as thermogravimetric (TGA) and differential thermal analysis (DTA). In vitro antibacterial activities of the ligands, salt, and complexes were tested against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) and they were compared with tetracycline. The complexes showed antibacterial activities against the tested pathogens. However, they showed lower activities than the reference. The target complex Fe(phen (BA)(Gu)(H2O)2]Cl2 showed inhibition zones 12±1 on S. aureus and 12±0.58mm on E.coli. It is also less active than the ligands as well as the salt. This result indicates the combination of the complex to be inappropriate to serve as antibacterial agent. However, the complex could be investigated for other applications including for electrochemical applications.

2024-07-01T00:00:00Z Girma, Kassahun http://ir.bdu.edu.et/handle/123456789/16797 2025-07-28T12:20:33Z 2024-07-01T00:00:00Z

Synthesis, Structural Investigation And Antibacterial Activity Study Of Iron(Iii) Complex With Cytosine, Benzoic Acid And 1,10- Phenanthroline’ Girma, Kassahun n this study three Iron(III) complexes with 1,10-Phenanthroline, benzoic acid, and Cytosine (viz. [Fe(Phen)(H2O)4]Cl3, [Fe(Phen)(BA)(H2O)3]Cl3 and [Fe(Phen)(BA)(Cyt)(H2O)2]Cl3, where synthesized and characterized. The complexes were synthesized in solution and characterized using physicochemical (conductivity measurement, Melting point, chloride test, solubility test, thermal analysis (TGA), and spectroscopic techniques (IR and UV-visible). Based on the analytical and spectroscopic data, octahedral geometries are assigned to the complexes. The in vitro antibacterial activity was tested on one Gram-positive Staphylococcus aureus (S. aureus) and one Gram-negative Escherichia coli (E. Coli) bacteria using the disc diffusion method. The complexes demonstrated appreciable activity against both pathogens. The antibacterial activity of the synthesized complexes showed less activity than the commercial antibiotic tetracycline against all the strains studied (S. aureus and E. coli). The percent activity of [Fe(Phen)(H2O)4]Cl3 complex showed better antibacterial activity than synthesized [Fe(Phen)(BA)(H2O)3]Cl3 and [Fe(Phen)(BA)(Cyt)(H2O)2]Cl3 complex in Gram negative (E. coli) bacteria. The results provide an insight to design and readily prepare task-specific metal-based drugs for interaction with particular bacterial strains.

2024-07-01T00:00:00Z Emeye, Tewachew http://ir.bdu.edu.et/handle/123456789/16795 2025-07-28T12:11:02Z 2024-07-01T00:00:00Z

Synthesis, Characterization and Antibacterial Activity Study of Cobalt(II) Complexes with 1, 10- phenanthroline and chrysin Emeye, Tewachew n this study, two complexes (one precursor and one new) were synthesized from 1,10- phenanthroline alone as [Co(phen)2(H2O)2]Cl2 and from both 1,10-phenanthroline and chrysin as [Co(phen)(chry)]Cl2.1.25H2O. The synthesis was checked using physicochemical techniques (solubility tests, molar conductivity, melting point, chloride test, metal determination and TGA) and spectroscopic techniques (UV-Vis and FT-IR). Based on the above data a tetrahedral geometry were proposed for both complexes. The In vitro antibacterial activities of the two metal complexes were tested against one Gram-positive Staphylococcus aureus (S. aureus) and one Gram-negative Escherichia coli (E.coli) bacteria using the disc diffusion method. Cobalt(II) complexes were active against Gram-negative bacteria (Escherichia coli) even though well known for their activity against Gram-positive bacteria. However the result shows the two complexes were less active compared to the commercial antibiotic drug tetracycline in all bacteria strains. Keywords: Co(II) complexes, 1,1 0-phenanthroline, Chrysin, antibacterial activity

2024-07-01T00:00:00Z Genet, Wubet http://ir.bdu.edu.et/handle/123456789/16792 2025-07-28T11:28:41Z 2024-12-01T00:00:00Z

Green Synthesis and Characterization Of Iron(III)Oxide(Fe304) Nanoparticles Using HageniaaAbyssinica (KOSSO)Leaf Extract And Its Antibacterial Activities Genet, Wubet In this study, leaf extract from Hageniaabyssinica (kosso) was added to hexa hydrate ferric chloride (FeCl3.6H2O) to transform it into iron oxide nanoparticles (Fe3O4NPs). FTIR, XRD, and UV-visible measurements were employed to validate the generation of the iron oxide nanoparticles and to thoroughly describe them. The presence of active flavonoids, phenolic groups, alkaloids, and tannins in the biomass of the kosso leaf extract reduction was ascertained using FT-IR Spectroscopy and qualitative screening methods (searching for color changes).The green synthesis iron oxide nanoparticles were characterized by UV-Visible, FT-IR, and XRD spectroscopes. The reduction process was simple to handle and was monitored by UV-Visible spectroscopy that showed surface plasmon resonance (SPR) of the IONPs at 300 nm. This outcome unequivocally demonstrated that Fe3O4NPs were formed. The size and structure of the crystal were assessed using X-ray diffraction. The average particle size of Fe3O4 NPs12.21nm using the line width of the plane, refraction peak using the Scherrer’s equation. The antibacterial properties of green produced iron oxide nanoparticles against Gram +ve and Gram -ve bacteria were assessed. Iron oxide nanoparticles showed the least amount of efficacy against Staphylococcus aureus and the greatest zone of inhibition against Escherichia coli.

2024-12-01T00:00:00Z